News

Representatives of the Council of Rectors of the North-West Region have visited our Center with an introductory tour. The guests got acquainted with the equipment and learned the principles of Center’s work.
News on the site of the University.

Julia R. Shakirova, Elena V. Grachova, Antti J. Karttunen, Vladislav V. Gurzhiy, Sergey P. Tunik and Igor O. Koshevoy

«Metallophilicity-assisted assembly of phosphine-based cage molecules»

Dalton Trans., 2014, Advance Article

DOI: 10.1039/c3dt53645a

A family of supramolecular cage molecules has been obtained via self-assembly of the phosphine–gold coordination complexes following an aurophilicity-driven aggregation approach. Use of the di- (PP) or tridentate (PPP) phosphine ligands Pn (n = 2, 3) with rigid polyaromatic backbones leads to clean formation of the coordination Pn(Au(tht))nⁿ⁺ species, sequential treatment of which with H2O/NEt3 and excess of H2NBut gives the finite 3D structures of two major types. The cylindrical-like hexametallic cages [(PPAu2)3(μ3-NBu^t)2]²⁺ are based on the diphosphines PP = 1,4-bis(diphenylphosphino)benzene (1), 4,4′-bis(diphenylphosphino)biphenyl (2), 4,4′′-bis(diphenylphosphino)terphenyl (3), while the triphosphine PPP (1,3,5-tris(diphenylphosphinophenyl)benzene) produces a tetrahedral dodecagold complex [(PPPAu3)4(μ3-NBut)4]4+ (4). The cages 1–4 have been studied using the ESI-MS and ¹H, ³¹P NMR spectroscopy, and the crystal structures of 1 and 4 were determined by an X-ray diffraction study. The NMR spectroscopic investigations showed that cylindrical complexes 1–3 undergo twisting-like interconversion of the helical P↔M isomers in solution, while 4 is a stereochemically rigid compound retaining its axially chiral architecture. The difference in dynamic behaviour was rationalized using computational studies with density functional methods.

M. A. Kuznetsov, A. Ya. Bespalov

«One-pot, Three-component Synthesis of [1,3]thiazolo[4,3-b][1,3,4]thiadiazoles: Correct Structure of the Products»

Chem. Heterocycl. Compd., 2014, 49, 1458-1463

DOI: 10.1007/s10593-014-1396-4

The products of the one-pot, three-component synthesis of [1,3]thiazolo-[4,3-b][1, 3, 4]thiadiazoles from aromatic aldehydes, thioglycolic acid, and compounds containing a C(=S)–N–NH2 fragment (thiosemicarbazide or 4-amino-2,4-dihydro-3H-1,2,4-triazole-3-thiones) are not condensed hetero-cycles (as reported by several researchers), but are thiosemicarbazones or triazolylimines of the aldehydes used.

Within the multidisciplinary seminars conducted by our Center, on March 13th and 20th there will be a lecture by Professor Miklos Gratzl of the Case Western Reserve University, USA, united by a common theme «Experimental approaches to study cellular and multicellular drug transport in cancer cells».

In this sequence of talks mechanisms of drug transport at single cells and in 3D multicellular constructs will be briefly reviewed. Experimental approaches to study some of these processes will then be presented in more detail. At the cellular level, drug delivery into single cells via passive and forced uptake and associated processes will be discussed. At the multicellular level, drug penetration, modulation of therapeutic efficacy by local hypoxia and acidification, and distribution of cell kill will be outlined based on the spheroid model, the microfluidic approach, and a new physical model of the capillary microenvironment. Movement of a classical small drug molecule and a plant‐ derived viral nano‐delivery vehicle will be discussed in these contexts.

Seminars will take place at 12:00 in room 1093 of the Chemical Faculty. There will be some tea, coffee and cookies. The lectures will be in English.

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