Julia R. Shakirova, Elena V. Grachova, Antti J. Karttunen, Vladislav V. Gurzhiy, Sergey P. Tunik and Igor O. Koshevoy

«Metallophilicity-assisted assembly of phosphine-based cage molecules»

Dalton Trans., 2014, Advance Article

DOI: 10.1039/c3dt53645a

A family of supramolecular cage molecules has been obtained via self-assembly of the phosphine–gold coordination complexes following an aurophilicity-driven aggregation approach. Use of the di- (PP) or tridentate (PPP) phosphine ligands Pn (n = 2, 3) with rigid polyaromatic backbones leads to clean formation of the coordination Pn(Au(tht))nⁿ⁺ species, sequential treatment of which with H2O/NEt3 and excess of H2NBut gives the finite 3D structures of two major types. The cylindrical-like hexametallic cages [(PPAu2)3(μ3-NBu^t)2]²⁺ are based on the diphosphines PP = 1,4-bis(diphenylphosphino)benzene (1), 4,4′-bis(diphenylphosphino)biphenyl (2), 4,4′′-bis(diphenylphosphino)terphenyl (3), while the triphosphine PPP (1,3,5-tris(diphenylphosphinophenyl)benzene) produces a tetrahedral dodecagold complex [(PPPAu3)4(μ3-NBut)4]4+ (4). The cages 1–4 have been studied using the ESI-MS and ¹H, ³¹P NMR spectroscopy, and the crystal structures of 1 and 4 were determined by an X-ray diffraction study. The NMR spectroscopic investigations showed that cylindrical complexes 1–3 undergo twisting-like interconversion of the helical P↔M isomers in solution, while 4 is a stereochemically rigid compound retaining its axially chiral architecture. The difference in dynamic behaviour was rationalized using computational studies with density functional methods.

В рамках мультидисциплинарных семинаров, проводимых РЦ «Магнитно-резонансные методы исследования», 13 и 20 марта пройдут лекции профессора Миклоша Гратцля (Miklos Gratzl) из кливлендского университета (Case Western Reserve University, США), объединенные общей темой «Experimental approaches to study cellular and multicellular drug transport in cancer cells».

In this sequence of talks mechanisms of drug transport at single cells and in 3D multicellular constructs will be briefly reviewed. Experimental approaches to study some of these processes will then be presented in more detail. At the cellular level, drug delivery into single cells via passive and forced uptake and associated processes will be discussed. At the multicellular level, drug penetration, modulation of therapeutic efficacy by local hypoxia and acidification, and distribution of cell kill will be outlined based on the spheroid model, the microfluidic approach, and a new physical model of the capillary microenvironment. Movement of a classical small drug molecule and a plant‐ derived viral nano‐delivery vehicle will be discussed in these contexts.

Приглашаются все желающие. Особенно будем рады студентам и аспирантам.

Семинары пройдут в к. 1093 (конференц-зал РЦ РДМИ). Начало в 12:00. Пришедшим будет предложен чай, кофе, печеньки. Лекции будут на английском языке.