Titration, dissolution and sorption calorimetry

The most flexible and efficient unit, allowing measurements with very high sensitivity and accuracy.



TAM III is the new generation, multi-channel, microcalorimetric system from TA Instruments. TAM offers maximum sensitivity, flexibility, and performance. It can be used with the most sensitive microcalorimeters and a wide variety of accessories to precisely control the experimental conditions. Up to four independent calorimeters can be used simultaneously with TAM III, to perform repetitive or different types of experiments. TAM III is totally modular and enables multiple calorimeters to be added to increase sample capacity or functionality. With the addition of a multicalorimeter holding six independent minicalorimeters, the sample throughput is substantially increased. TAM III employs patented thermostat technology to precisely control the liquid bath temperature to within 0.0001°C, and can be operated in isothermal, step-isothermal or temperature-scanning mode.


Isothermal Mode - is the classical mode for microcalorimetric experiments. The liquid thermostat is maintained at constant temperature for the duration of the experiment. Any heat generated or absorbed by the sample due to a chemical or physical process is continuously measured. Isothermal measurements give quantitative and continuous data reflecting the rate of the process under study.

Step Isothermal Mode - step isothermal experiments can be performed on the same sample at different temperatures. During the isothermal phases, the same signal stability and sensitivity is achieved as with conventional isothermal experiments. During the temperature transition phases, heat flow is recorded to monitor how the sample is affected by the change in temperature. This mode is useful for the study of heat capacity and temperature dependence of chemical reactions.


The Nanocalorimeter is the most sensitive calorimeter for TAM III, and is typically used in the isothermal mode. It combines high sensitivity with excellent baseline stability which makes it ideal for isothermal titration calorimetry (ITC) in studying molecular interactions. The nanocalorimeter holds all closed ampoules up to 5 ml. For highest sensitivity it is used with the 1 ml titration ampoule and a similar ampoule as reference. This reference ampoule contains an inert substance, in order to balance the heat capacity of the two sides.


The 20 ml Microcalorimeter is a heat flow calorimeter of twin type. It has been designed to hold large samples, and for experiments requiring a large gas phase above the sample. The microcalorimeter can be used with all 20 ml static ampoules and the 20 ml micro reaction system including titration facilities and control of the relative humidity during measurement. The 20 ml Microcalorimeter is also the only calorimeter that can be used with the micro solution ampoule. This ampoule is designed for dissolution of very small amounts of solids (a few mg) in different solvents and is ideal for dissolution of slowly soluble substances. The heat of dissolution and the kinetics of dissolution can be studied.

ТАМ III  Specifications

Calorimeter Positions


Temperature Range


Temperature Accuracy

< ± 0.1°C

Long Term Stability

< ± 100 μK/24h

Short Term Stability

< ± 10 μK (p-p)

Scanning Rate (between 20-150 °C)

< ± 2°C/h

Heating (step-wise change)

15°C/h at 15°C - 2°C/h at 150°C

Cooling (step-wise change)

15°C/h at 150°C - 1.5°C/h at 15°C

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