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P. R. Golubev, A. S. Pankova, M. A. Kuznetsov

“Transition-Metal-Free Approach to 4-Ethynylpyrimidines via Alkenynones”

Eur. J. Org. Chem. 2014, 3614-3621

DOI: 10.1002/ejoc.201402045

A practical approach to the synthesis of 4-ethynylpyrimidines by the condensation of arylamidines with 2-aryl-1-ethoxy-5-(trimethylsilyl)pent-1-en-4-yn-3-ones has been developed. As these latter ketones are easily accessible from bis(trimethylsilyl)acetylene and arylacetyl chlorides, the regioselective condensation reported herein provides a facile access to both TMS-protected and unprotected 4-ethynylpyrimidines in yields of up to 85%.

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17 июня в 15:00 в лектории Менделеевского центра состоится лекция профессора Hans-Heinrich Limbach из Dahlem Research School of Molecular Sciences of the Freie Universität Berlin, Germany:

«Functional hydrogen bond NMR: from model systems to nano catalysts and enzymes»

Адрес: СПб, Университетская наб. 7/9, здание НИХИ. Для прохода на территорию университета необходимо предъявить паспорт. Проезд на троллейбусах 1, 7, 10 и автобусах 7, 24, 47, 171. Справки по тел. 323-41-20.

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11 июня — укороченный рабочий день
12-15 июня — выходные дни

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M. Popova, D. Michel

«Behavior of Sodium Lauroyl Sarcosinate in Solution and Binary Mixtures by Means NMR»

Applied Magnetic Resonance 2014, 45, 353-364

DOI 10.1007/s00723-014-0531-9

Measurements of the ¹H and ¹³C chemical shifts as well as ¹H spin–lattice relaxation times of sodium lauroyl sarcosinate (SLAS) in aqueous solutions and mixed binary systems with co-surfactants were carried out at various concentrations. It will be shown that changes in the chemical shifts for the N–CH2 groups in SLAS with increasing surfactant concentration can be used to estimate the ratio pcis /ptrans of cis- and trans-isomers. The relative fraction p trans of molecules in trans-configurations increases the most in a narrow concentration range 0.007–0.034 mol/l, i.e., at the transition from the monomeric state to the micelle. The ratio pcis /ptrans asymptotically decreases with increasing concentration, reaching a constant value at concentrations significantly above the critical micelle concentration. Thus, the ratio can be related to the process of micellization. If micellization takes place, the cis-isomer starts to transform into trans-isomer because the trans-isomer is more favorable in micelles. Because of the smaller cross section of the polar group region, the trans-conformation can be more easily incorporated into the micelle. In summary, the occurrence of micellar aggregates at low SLAS concentration in mixed systems can be clearly inferred from the nuclear magnetic resonance spectra.