Within the multidisciplinary seminars conducted by our Center, on March 13th and 20th there will be a lecture by Professor Miklos Gratzl of the Case Western Reserve University, USA, united by a common theme «Experimental approaches to study cellular and multicellular drug transport in cancer cells».

In this sequence of talks mechanisms of drug transport at single cells and in 3D multicellular constructs will be briefly reviewed. Experimental approaches to study some of these processes will then be presented in more detail. At the cellular level, drug delivery into single cells via passive and forced uptake and associated processes will be discussed. At the multicellular level, drug penetration, modulation of therapeutic efficacy by local hypoxia and acidification, and distribution of cell kill will be outlined based on the spheroid model, the microfluidic approach, and a new physical model of the capillary microenvironment. Movement of a classical small drug molecule and a plant‐ derived viral nano‐delivery vehicle will be discussed in these contexts.

Seminars will take place at 12:00 in room 1093 of the Chemical Faculty. There will be some tea, coffee and cookies. The lectures will be in English.

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Ilya S. Krytchankou, Dmitry V. Krupenya, Antti J. Karttunen, Sergey P. Tunik, Tapani A. Pakkanen, Pi-Tai Choud, Igor O. Koshevoy
«Triphosphine-supported bimetallic AuI–MI (M = Ag, Cu) alkynyl clusters»
Dalton Trans., 2014, Advance Article
DOI: 10.1039/C3DT52658E

The luminescent bimetallic aggregates reversibly undergo dissociation or isomerization in solution and exhibit photoemission in the solid state (414 to 566 nm).

Andrey Gurinov has completed the training in the University of Guadalajara, Mexico, and received a certificate.

Members of the International Committee on Science Policy of the National Research Center “Kurchatov Institute” have visited our Center. The guests got acquainted with the equipment and learned the Center’s work. Dean of the Faculty of Physics, director of the Kurchatov Center Mikhail Kovalchuk invited committee members – representatives of CERN (Switzerland), Max-Born-Institute (Germany), DESY (Germany), Royal Institute of Technology (Sweden), Neutron Center of Budapest (Hungary), Joint Institute for Nuclear research (Dubna) and other research centers – to come to St. Petersburg State University so they can see how science develops at the St. Petersburg University.

At the University of Guadalajara, Mexico, Andrey Gurinov has told about the Center, its equipment, the ongoing researches and opportunities for collaboration, and then presented a talk about the NMR studies ​​of aluminated mesoporous silicas.